Velban
Velban Brand names, Velban Analogs
Velban Brand Names Mixture
- No information avaliable
Velban Chemical_Formula
C46H58N4O9
Velban RX_link
http://www.rxlist.com/cgi/generic3/vinblastine.htm
Velban fda sheet
Velban msds (material safety sheet)
Velban Synthesis Reference
No information avaliable
Velban Molecular Weight
810.974 g/mol
Velban Melting Point
267 oC
Velban H2O Solubility
Negligible
Velban State
Solid
Velban LogP
5.587
Velban Dosage Forms
Liquid; Powder for solution; Solution
Velban Indication
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
Velban Pharmacology
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Velban Absorption
No information avaliable
Velban side effects and Toxicity
Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
Velban Patient Information
Velban Organisms Affected
Humans and other mammals
