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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C46H58N4O9
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RX_link
http://www.rxlist.com/cgi/generic3/vinblastine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
810.974 g/mol
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Melting Point
267 oC
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H2O Solubility
Negligible
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State
Solid
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LogP
5.587
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Dosage Forms
Liquid; Powder for solution; Solution
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Indication
For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.
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Pharmacology
Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
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Absorption
No information avaliable
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side effects and Toxicity
Oral, mouse: LD50 = 423 mg/kg; Oral, rat: LD50 = 305 mg/kg.
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Patient Information
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Organisms Affected
Humans and other mammals