Vincoblastine

Vincoblastine Brand names, Vincoblastine Analogs

Vincoblastine Brand Names Mixture

No information avaliable

Vincoblastine Chemical_Formula

C₄₆H₅₈N₄O₉

Vincoblastine RX_link

http://www.rxlist.com/cgi/generic3/vinblastine.htm

Vincoblastine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/summary.cfm?ID=29

Vincoblastine msds (material safety sheet)

Vincoblastine MSDS

Vincoblastine Synthesis Reference

No information avaliable

Vincoblastine Molecular Weight

810.974 g/mol

Vincoblastine Melting Point

267 ^oC

Vincoblastine H₂O Solubility

Negligible

Vincoblastine State

Solid

Vincoblastine LogP

5.587

Vincoblastine Dosage Forms

Liquid; Powder for solution; Solution

Vincoblastine Indication

For treatment of breast cancer, testicular cancer, lymphomas, neuroblastoma, Hodgkin's and non-Hodgkin's lymphomas, mycosis fungoides, histiocytosis, and Kaposi's sarcoma.

Vincoblastine Pharmacology

Vinblastine is a vinca alkaloid antineoplastic agent. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units: vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinblastine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.

Vincoblastine Absorption