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Brand names,
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Analogs
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Brand Names Mixture
- Apo Triazide Tab (Hydrochlorothiazide + Triamterene)
- Dyazide Tab (Hydrochlorothiazide + Triamterene)
- Novo-Triamzide (Hydrochlorothiazide + Triamterene)
- Nu-Triazide Tab 50 Mg/25 Mg (Hydrochlorothiazide + Triamterene)
- Penta-Triamterene HCTZ Tablets (Hydrochlorothiazide + Triamterene)
- Pro-Triazide (Hydrochlorothiazide + Triamterene)
- Riva-Zide 50/25mg Tablets (Hydrochlorothiazide + Triamterene)
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Chemical_Formula
C12H11N7
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RX_link
http://www.rxlist.com/cgi/generic/triamterine.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Spickett, Timmis, J. Chem.. Soc. 1954, 2887 (1958)
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Molecular Weight
253.263 g/mol
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Melting Point
316 oC
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H2O Solubility
48.2 mg/L
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State
Solid
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LogP
-0.323
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Dosage Forms
Tablet
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Indication
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism.
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Pharmacology
Triamterene, a relatively weak, potassium-sparing distal tubule diuretic and antihypertensive, is used in the management of hypokalemia. Triamterene is similar in action to amiloride but, unlike amiloride, increases the urinary excretion of magnesium.
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Absorption
Rapidly absorbed, with somewhat less than 50% of the oral dose reaching the urine.
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side effects and Toxicity
No information avaliable
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Patient Information
Information for Patients
To help avoid stomach upset, it is recommended that the drug be taken after meals.
If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of
increased frequency of urination on nighttime sleep.
If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval.
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Organisms Affected
Humans and other mammals