Pterophene
Brand names,
Pterophene
Analogs
Pterophene
Brand Names Mixture
- Apo Triazide Tab (Hydrochlorothiazide + Triamterene)
- Dyazide Tab (Hydrochlorothiazide + Triamterene)
- Novo-Triamzide (Hydrochlorothiazide + Triamterene)
- Nu-Triazide Tab 50 Mg/25 Mg (Hydrochlorothiazide + Triamterene)
- Penta-Triamterene HCTZ Tablets (Hydrochlorothiazide + Triamterene)
- Pro-Triazide (Hydrochlorothiazide + Triamterene)
- Riva-Zide 50/25mg Tablets (Hydrochlorothiazide + Triamterene)
Pterophene
Chemical_Formula
C12H11N7
Pterophene
RX_link
http://www.rxlist.com/cgi/generic/triamterine.htm
Pterophene
fda sheet
Pterophene
msds (material safety sheet)
Pterophene
Synthesis Reference
Spickett, Timmis, J. Chem.. Soc. 1954, 2887 (1958)
Pterophene
Molecular Weight
253.263 g/mol
Pterophene
Melting Point
316 oC
Pterophene
H2O Solubility
48.2 mg/L
Pterophene
State
Solid
Pterophene
LogP
-0.323
Pterophene
Dosage Forms
Tablet
Pterophene
Indication
For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and the nephrotic syndrome; also in steroid-induced edema, idiopathic edema, and edema due to secondary hyperaldosteronism.
Pterophene
Pharmacology
Triamterene, a relatively weak, potassium-sparing distal tubule diuretic and antihypertensive, is used in the management of hypokalemia. Triamterene is similar in action to amiloride but, unlike amiloride, increases the urinary excretion of magnesium.
Pterophene
Absorption
Rapidly absorbed, with somewhat less than 50% of the oral dose reaching the urine.
Pterophene
side effects and Toxicity
No information avaliable
Pterophene
Patient Information
Information for Patients
To help avoid stomach upset, it is recommended that the drug be taken after meals.
If a single daily dose is prescribed, it may be preferable to take it in the morning to minimize the effect of
increased frequency of urination on nighttime sleep.
If a dose is missed, the patient should not take more than the prescribed dose at the next dosing interval.
Pterophene
Organisms Affected
Humans and other mammals