Trimox
Brand names,
Trimox
Analogs
Trimox
Brand Names Mixture
- Co-amoxiclav (amoxicillin + clavulanic acid)
- Augmentin (amoxicillin + clavulanic acid)
- Prevpac (amoxicillin + clarithromycin + lansoprazole)
Trimox
Chemical_Formula
C16H19N3O5S
Trimox
RX_link
http://www.rxlist.com/cgi/generic/amox.htm
Trimox
fda sheet
Trimox
msds (material safety sheet)
Trimox
Synthesis Reference
Nayler, Smith, U.S. Pat. 3,192,198 (1965)
Trimox
Molecular Weight
365.405 g/mol
Trimox
Melting Point
194 oC
Trimox
H2O Solubility
3430 mg/L
Trimox
State
Solid
Trimox
LogP
-0.124
Trimox
Dosage Forms
Capsule (250 mg or 500 mg); Powder for solution; Powder for suspension; Suspension; Tablet (500 mg or 875 mg)
Trimox
Indication
For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Trimox
Pharmacology
Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
Trimox
Absorption
Rapidly absorbed after oral administration.
Trimox
side effects and Toxicity
Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Trimox
Patient Information
Amoxicillin is an antibiotic for treatment of infection.
Take at regular intervals, around the clock. Always finish course of therapy.
Take with or without meals.
May cause serious allergic reactions in those with penicillin allergy.
May cause nausea, vomiting and diarrhea; notify your doctor or pharmacist if these occur.
Trimox
Organisms Affected
Enteric bacteria and other eubacteria