Amoxibiotic
Brand names,
Amoxibiotic
Analogs
Amoxibiotic
Brand Names Mixture
- Co-amoxiclav (amoxicillin + clavulanic acid)
- Augmentin (amoxicillin + clavulanic acid)
- Prevpac (amoxicillin + clarithromycin + lansoprazole)
Amoxibiotic
Chemical_Formula
C16H19N3O5S
Amoxibiotic
RX_link
http://www.rxlist.com/cgi/generic/amox.htm
Amoxibiotic
fda sheet
Amoxibiotic
msds (material safety sheet)
Amoxibiotic
Synthesis Reference
Nayler, Smith, U.S. Pat. 3,192,198 (1965)
Amoxibiotic
Molecular Weight
365.405 g/mol
Amoxibiotic
Melting Point
194 oC
Amoxibiotic
H2O Solubility
3430 mg/L
Amoxibiotic
State
Solid
Amoxibiotic
LogP
-0.124
Amoxibiotic
Dosage Forms
Capsule (250 mg or 500 mg); Powder for solution; Powder for suspension; Suspension; Tablet (500 mg or 875 mg)
Amoxibiotic
Indication
For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Amoxibiotic
Pharmacology
Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
Amoxibiotic
Absorption
Rapidly absorbed after oral administration.
Amoxibiotic
side effects and Toxicity
Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Amoxibiotic
Patient Information
Amoxicillin is an antibiotic for treatment of infection.
Take at regular intervals, around the clock. Always finish course of therapy.
Take with or without meals.
May cause serious allergic reactions in those with penicillin allergy.
May cause nausea, vomiting and diarrhea; notify your doctor or pharmacist if these occur.
Amoxibiotic
Organisms Affected
Enteric bacteria and other eubacteria