Ospamox
Brand names,
Ospamox
Analogs
Ospamox
Brand Names Mixture
- Co-amoxiclav (amoxicillin + clavulanic acid)
- Augmentin (amoxicillin + clavulanic acid)
- Prevpac (amoxicillin + clarithromycin + lansoprazole)
Ospamox
Chemical_Formula
C16H19N3O5S
Ospamox
RX_link
http://www.rxlist.com/cgi/generic/amox.htm
Ospamox
fda sheet
Ospamox
msds (material safety sheet)
Ospamox
Synthesis Reference
Nayler, Smith, U.S. Pat. 3,192,198 (1965)
Ospamox
Molecular Weight
365.405 g/mol
Ospamox
Melting Point
194 oC
Ospamox
H2O Solubility
3430 mg/L
Ospamox
State
Solid
Ospamox
LogP
-0.124
Ospamox
Dosage Forms
Capsule (250 mg or 500 mg); Powder for solution; Powder for suspension; Suspension; Tablet (500 mg or 875 mg)
Ospamox
Indication
For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Ospamox
Pharmacology
Amoxicillin is a moderate-spectrum antibiotic active against a wide range of Gram-positive, and a limited range of Gram-negative organisms. It is usually the drug of choice within the class because it is better absorbed, following oral administration, than other beta-lactam antibiotics. Amoxicillin is susceptible to degradation by β-lactamase-producing bacteria, and so may be given with clavulanic acid to increase its susceptability. The incidence of β-lactamase-producing resistant organisms, including E. coli, appears to be increasing. Amoxicillin is sometimes combined with clavulanic acid, a β-lactamase inhibitor, to increase the spectrum of action against Gram-negative organisms, and to overcome bacterial antibiotic resistance mediated through β-lactamase production.
Ospamox
Absorption
Rapidly absorbed after oral administration.
Ospamox
side effects and Toxicity
Serious toxicity is unlikely following large doses of amoxicillin. Acute ingestion of large doses of amoxicillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses.
Ospamox
Patient Information
Amoxicillin is an antibiotic for treatment of infection.
Take at regular intervals, around the clock. Always finish course of therapy.
Take with or without meals.
May cause serious allergic reactions in those with penicillin allergy.
May cause nausea, vomiting and diarrhea; notify your doctor or pharmacist if these occur.
Ospamox
Organisms Affected
Enteric bacteria and other eubacteria