Topotecan Lactone
Topotecan Lactone Brand names, Topotecan Lactone Analogs
Topotecan Lactone Brand Names Mixture
- No information avaliable
Topotecan Lactone Chemical_Formula
C23H23N3O5
Topotecan Lactone RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Topotecan Lactone fda sheet
Topotecan Lactone msds (material safety sheet)
Topotecan Lactone Synthesis Reference
No information avaliable
Topotecan Lactone Molecular Weight
421.446 g/mol
Topotecan Lactone Melting Point
213-218 oC
Topotecan Lactone H2O Solubility
1 mg/ml
Topotecan Lactone State
Solid
Topotecan Lactone LogP
1.21
Topotecan Lactone Dosage Forms
Powder for solution
Topotecan Lactone Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Topotecan Lactone Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Topotecan Lactone Absorption
No information avaliable
Topotecan Lactone side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Topotecan Lactone Patient Information
No information avaliable
Topotecan Lactone Organisms Affected
Humans and other mammals
