Hycamptin
Hycamptin Brand names, Hycamptin Analogs
Hycamptin Brand Names Mixture
- No information avaliable
Hycamptin Chemical_Formula
C23H23N3O5
Hycamptin RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Hycamptin fda sheet
Hycamptin msds (material safety sheet)
Hycamptin Synthesis Reference
No information avaliable
Hycamptin Molecular Weight
421.446 g/mol
Hycamptin Melting Point
213-218 oC
Hycamptin H2O Solubility
1 mg/ml
Hycamptin State
Solid
Hycamptin LogP
1.21
Hycamptin Dosage Forms
Powder for solution
Hycamptin Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Hycamptin Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Hycamptin Absorption
No information avaliable
Hycamptin side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Hycamptin Patient Information
No information avaliable
Hycamptin Organisms Affected
Humans and other mammals
