Topotecan Hydrochloride
Topotecan Hydrochloride Brand names, Topotecan Hydrochloride Analogs
Topotecan Hydrochloride Brand Names Mixture
- No information avaliable
Topotecan Hydrochloride Chemical_Formula
C23H23N3O5
Topotecan Hydrochloride RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Topotecan Hydrochloride fda sheet
Topotecan Hydrochloride msds (material safety sheet)
Topotecan Hydrochloride Synthesis Reference
No information avaliable
Topotecan Hydrochloride Molecular Weight
421.446 g/mol
Topotecan Hydrochloride Melting Point
213-218 oC
Topotecan Hydrochloride H2O Solubility
1 mg/ml
Topotecan Hydrochloride State
Solid
Topotecan Hydrochloride LogP
1.21
Topotecan Hydrochloride Dosage Forms
Powder for solution
Topotecan Hydrochloride Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Topotecan Hydrochloride Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Topotecan Hydrochloride Absorption
No information avaliable
Topotecan Hydrochloride side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Topotecan Hydrochloride Patient Information
No information avaliable
Topotecan Hydrochloride Organisms Affected
Humans and other mammals
