TTC
TTC Brand names, TTC Analogs
TTC Brand Names Mixture
- No information avaliable
TTC Chemical_Formula
C23H23N3O5
TTC RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
TTC fda sheet
TTC msds (material safety sheet)
TTC Synthesis Reference
No information avaliable
TTC Molecular Weight
421.446 g/mol
TTC Melting Point
213-218 oC
TTC H2O Solubility
1 mg/ml
TTC State
Solid
TTC LogP
1.21
TTC Dosage Forms
Powder for solution
TTC Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
TTC Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
TTC Absorption
No information avaliable
TTC side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
TTC Patient Information
No information avaliable
TTC Organisms Affected
Humans and other mammals
