TPT
TPT Brand names, TPT Analogs
TPT Brand Names Mixture
- No information avaliable
TPT Chemical_Formula
C23H23N3O5
TPT RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
TPT fda sheet
TPT msds (material safety sheet)
TPT Synthesis Reference
No information avaliable
TPT Molecular Weight
421.446 g/mol
TPT Melting Point
213-218 oC
TPT H2O Solubility
1 mg/ml
TPT State
Solid
TPT LogP
1.21
TPT Dosage Forms
Powder for solution
TPT Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
TPT Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
TPT Absorption
No information avaliable
TPT side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
TPT Patient Information
No information avaliable
TPT Organisms Affected
Humans and other mammals
