Hycamtin
Hycamtin Brand names, Hycamtin Analogs
Hycamtin Brand Names Mixture
- No information avaliable
Hycamtin Chemical_Formula
C23H23N3O5
Hycamtin RX_link
http://www.rxlist.com/cgi/generic2/topotec.htm
Hycamtin fda sheet
Hycamtin msds (material safety sheet)
Hycamtin Synthesis Reference
No information avaliable
Hycamtin Molecular Weight
421.446 g/mol
Hycamtin Melting Point
213-218 oC
Hycamtin H2O Solubility
1 mg/ml
Hycamtin State
Solid
Hycamtin LogP
1.21
Hycamtin Dosage Forms
Powder for solution
Hycamtin Indication
For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy.
Hycamtin Pharmacology
Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug.
Hycamtin Absorption
No information avaliable
Hycamtin side effects and Toxicity
The primary anticipated complication of overdosage would consist of bone marrow suppression.
Hycamtin Patient Information
No information avaliable
Hycamtin Organisms Affected
Humans and other mammals
