Ternadin
Ternadin Brand names, Ternadin Analogs
Ternadin Brand Names Mixture
- No information avaliable
Ternadin Chemical_Formula
C32H41NO2
Ternadin RX_link
http://www.rxlist.com/cgi/generic/terfen.htm
Ternadin fda sheet
Ternadin msds (material safety sheet)
Ternadin Synthesis Reference
A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)
Ternadin Molecular Weight
471.673 g/mol
Ternadin Melting Point
146.5-148.5oC
Ternadin H2O Solubility
10 mg/L
Ternadin State
Solid
Ternadin LogP
7.784
Ternadin Dosage Forms
Oral tablets
Ternadin Indication
For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Ternadin Pharmacology
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.
Ternadin Absorption
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
Ternadin side effects and Toxicity
Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
Ternadin Patient Information
Ternadin Organisms Affected
Humans and other mammals
