Teldane
Teldane Brand names, Teldane Analogs
Teldane Brand Names Mixture
- No information avaliable
Teldane Chemical_Formula
C32H41NO2
Teldane RX_link
http://www.rxlist.com/cgi/generic/terfen.htm
Teldane fda sheet
Teldane msds (material safety sheet)
Teldane Synthesis Reference
A. A. Carr, C. R. Kinsolving, U.S. Pat. 3,878,217 (1975)
Teldane Molecular Weight
471.673 g/mol
Teldane Melting Point
146.5-148.5oC
Teldane H2O Solubility
10 mg/L
Teldane State
Solid
Teldane LogP
7.784
Teldane Dosage Forms
Oral tablets
Teldane Indication
For the treatment of allergic rhinitis, hay fever, and allergic skin disorders.
Teldane Pharmacology
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine.
Teldane Absorption
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%
Teldane side effects and Toxicity
Mild (e.g., headache, nausea, confusion), but adverse cardiac events including cardiac arrest, ventricular arrhythmias including torsades de pointes and QT prolongation have been reported. LD50=mg/kg (orally in mice)
Teldane Patient Information
Teldane Organisms Affected
Humans and other mammals
