Selegiline Hcl
Brand names,
Selegiline Hcl
Analogs
Selegiline Hcl
Brand Names Mixture
Selegiline Hcl
Chemical_Formula
C13H17N
Selegiline Hcl
RX_link
http://www.rxlist.com/cgi/generic/seleg.htm
Selegiline Hcl
fda sheet
Selegiline Hcl
msds (material safety sheet)
Selegiline Hcl
Synthesis Reference
Torok Z et al., Acta Pharm Hung. 1992 Sep;62(5):201-11
Selegiline Hcl
Molecular Weight
187.281 g/mol
Selegiline Hcl
Melting Point
141-142 oC
Selegiline Hcl
H2O Solubility
No information avaliable
Selegiline Hcl
State
Solid
Selegiline Hcl
LogP
2.884
Selegiline Hcl
Dosage Forms
Tablet
Selegiline Hcl
Indication
For the adjunct treatment for Parkinson's disease.
Selegiline Hcl
Pharmacology
Dopamine is an essential chemical that occurs in many parts of the body. It is the premature degradation of dopamine that results in the symptoms of Parkinson's disease. Monoamine oxidase (MAO) is an enzyme which accelerates the breakdown of dopamine. Selegiline can prolong the effects of dopamine in the brain by preventing its breakdown through seletively blocking MAO. It also may prevent the removal of dopamine between nerve endings and enhance release of dopamine from nerve cells.
Selegiline Hcl
Absorption
Rapidly absorbed from the gastrointestinal tract.
Selegiline Hcl
side effects and Toxicity
LD50=63 mg/kg (rats, IV)
Selegiline Hcl
Patient Information
Selegiline Hcl
Organisms Affected
Humans and other mammals