Selegeline Hcl
Brand names,
Selegeline Hcl
Analogs
Selegeline Hcl
Brand Names Mixture
Selegeline Hcl
Chemical_Formula
C13H17N
Selegeline Hcl
RX_link
http://www.rxlist.com/cgi/generic/seleg.htm
Selegeline Hcl
fda sheet
Selegeline Hcl
msds (material safety sheet)
Selegeline Hcl
Synthesis Reference
Torok Z et al., Acta Pharm Hung. 1992 Sep;62(5):201-11
Selegeline Hcl
Molecular Weight
187.281 g/mol
Selegeline Hcl
Melting Point
141-142 oC
Selegeline Hcl
H2O Solubility
No information avaliable
Selegeline Hcl
State
Solid
Selegeline Hcl
LogP
2.884
Selegeline Hcl
Dosage Forms
Tablet
Selegeline Hcl
Indication
For the adjunct treatment for Parkinson's disease.
Selegeline Hcl
Pharmacology
Dopamine is an essential chemical that occurs in many parts of the body. It is the premature degradation of dopamine that results in the symptoms of Parkinson's disease. Monoamine oxidase (MAO) is an enzyme which accelerates the breakdown of dopamine. Selegiline can prolong the effects of dopamine in the brain by preventing its breakdown through seletively blocking MAO. It also may prevent the removal of dopamine between nerve endings and enhance release of dopamine from nerve cells.
Selegeline Hcl
Absorption
Rapidly absorbed from the gastrointestinal tract.
Selegeline Hcl
side effects and Toxicity
LD50=63 mg/kg (rats, IV)
Selegeline Hcl
Patient Information
Selegeline Hcl
Organisms Affected
Humans and other mammals