Novo-Selegiline
Brand names,
Novo-Selegiline
Analogs
Novo-Selegiline
Brand Names Mixture
Novo-Selegiline
Chemical_Formula
C13H17N
Novo-Selegiline
RX_link
http://www.rxlist.com/cgi/generic/seleg.htm
Novo-Selegiline
fda sheet
Novo-Selegiline
msds (material safety sheet)
Novo-Selegiline
Synthesis Reference
Torok Z et al., Acta Pharm Hung. 1992 Sep;62(5):201-11
Novo-Selegiline
Molecular Weight
187.281 g/mol
Novo-Selegiline
Melting Point
141-142 oC
Novo-Selegiline
H2O Solubility
No information avaliable
Novo-Selegiline
State
Solid
Novo-Selegiline
LogP
2.884
Novo-Selegiline
Dosage Forms
Tablet
Novo-Selegiline
Indication
For the adjunct treatment for Parkinson's disease.
Novo-Selegiline
Pharmacology
Dopamine is an essential chemical that occurs in many parts of the body. It is the premature degradation of dopamine that results in the symptoms of Parkinson's disease. Monoamine oxidase (MAO) is an enzyme which accelerates the breakdown of dopamine. Selegiline can prolong the effects of dopamine in the brain by preventing its breakdown through seletively blocking MAO. It also may prevent the removal of dopamine between nerve endings and enhance release of dopamine from nerve cells.
Novo-Selegiline
Absorption
Rapidly absorbed from the gastrointestinal tract.
Novo-Selegiline
side effects and Toxicity
LD50=63 mg/kg (rats, IV)
Novo-Selegiline
Patient Information
Novo-Selegiline
Organisms Affected
Humans and other mammals