Jumex
Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C13H17N
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RX_link
http://www.rxlist.com/cgi/generic/seleg.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Torok Z et al., Acta Pharm Hung. 1992 Sep;62(5):201-11
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Molecular Weight
187.281 g/mol
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Melting Point
141-142 oC
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H2O Solubility
No information avaliable
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State
Solid
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LogP
2.884
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Dosage Forms
Tablet
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Indication
For the adjunct treatment for Parkinson's disease.
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Pharmacology
Dopamine is an essential chemical that occurs in many parts of the body. It is the premature degradation of dopamine that results in the symptoms of Parkinson's disease. Monoamine oxidase (MAO) is an enzyme which accelerates the breakdown of dopamine. Selegiline can prolong the effects of dopamine in the brain by preventing its breakdown through seletively blocking MAO. It also may prevent the removal of dopamine between nerve endings and enhance release of dopamine from nerve cells.
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Absorption
Rapidly absorbed from the gastrointestinal tract.
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side effects and Toxicity
LD50=63 mg/kg (rats, IV)
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Patient Information
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Organisms Affected
Humans and other mammals