Preveon
Preveon Brand names, Preveon Analogs
Preveon Brand Names Mixture
- No information avaliable
Preveon Chemical_Formula
C20H32N5O8P
Preveon RX_link
http://www.rxlist.com/cgi/generic3/hepsera.htm
Preveon fda sheet
Preveon msds (material safety sheet)
Preveon Synthesis Reference
No information avaliable
Preveon Molecular Weight
501.471 g/mol
Preveon Melting Point
No information avaliable
Preveon H2O Solubility
19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.
Preveon State
Solid
Preveon LogP
3.649
Preveon Dosage Forms
Tablet (10 mg)
Preveon Indication
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Preveon Pharmacology
Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.
Preveon Absorption
Approximate oral bioavailability is 59%.
Preveon side effects and Toxicity
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
Preveon Patient Information
Preveon Organisms Affected
Hepatitis B virus
