Adefovirdipivoxl
Adefovirdipivoxl Brand names, Adefovirdipivoxl Analogs
Adefovirdipivoxl Brand Names Mixture
- No information avaliable
Adefovirdipivoxl Chemical_Formula
C20H32N5O8P
Adefovirdipivoxl RX_link
http://www.rxlist.com/cgi/generic3/hepsera.htm
Adefovirdipivoxl fda sheet
Adefovirdipivoxl msds (material safety sheet)
Adefovirdipivoxl Synthesis Reference
No information avaliable
Adefovirdipivoxl Molecular Weight
501.471 g/mol
Adefovirdipivoxl Melting Point
No information avaliable
Adefovirdipivoxl H2O Solubility
19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.
Adefovirdipivoxl State
Solid
Adefovirdipivoxl LogP
3.649
Adefovirdipivoxl Dosage Forms
Tablet (10 mg)
Adefovirdipivoxl Indication
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Adefovirdipivoxl Pharmacology
Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.
Adefovirdipivoxl Absorption
Approximate oral bioavailability is 59%.
Adefovirdipivoxl side effects and Toxicity
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
Adefovirdipivoxl Patient Information
Adefovirdipivoxl Organisms Affected
Hepatitis B virus
