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Adefovir Brand names, Adefovir Analogs

Adefovir Brand Names Mixture

  • No information avaliable

Adefovir Chemical_Formula


Adefovir RX_link

Adefovir fda sheet

Adefovir FDA

Adefovir msds (material safety sheet)

Adefovir MSDS

Adefovir Synthesis Reference

No information avaliable

Adefovir Molecular Weight

501.471 g/mol

Adefovir Melting Point

No information avaliable

Adefovir H2O Solubility

19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.

Adefovir State


Adefovir LogP


Adefovir Dosage Forms

Tablet (10 mg)

Adefovir Indication

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Adefovir Pharmacology

Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

Adefovir Absorption

Approximate oral bioavailability is 59%.

Adefovir side effects and Toxicity

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

Adefovir Patient Information

Adefovir Organisms Affected

Hepatitis B virus