Adefovir pivoxil en es it fr

Adefovir pivoxil Brand names, Adefovir pivoxil Analogs

Adefovir pivoxil Brand Names Mixture

  • No information avaliable

Adefovir pivoxil Chemical_Formula


Adefovir pivoxil RX_link

Adefovir pivoxil fda sheet

Adefovir_pivoxil FDA

Adefovir pivoxil msds (material safety sheet)

Adefovir_pivoxil MSDS

Adefovir pivoxil Synthesis Reference

No information avaliable

Adefovir pivoxil Molecular Weight

501.471 g/mol

Adefovir pivoxil Melting Point

No information avaliable

Adefovir pivoxil H2O Solubility

19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.

Adefovir pivoxil State


Adefovir pivoxil LogP


Adefovir pivoxil Dosage Forms

Tablet (10 mg)

Adefovir pivoxil Indication

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Adefovir pivoxil Pharmacology

Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

Adefovir pivoxil Absorption

Approximate oral bioavailability is 59%.

Adefovir pivoxil side effects and Toxicity

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

Adefovir pivoxil Patient Information

Adefovir pivoxil Organisms Affected

Hepatitis B virus