Hepsera en es it fr

Hepsera Brand names, Hepsera Analogs

Hepsera Brand Names Mixture

  • No information avaliable

Hepsera Chemical_Formula


Hepsera RX_link


Hepsera fda sheet

Hepsera FDA

Hepsera msds (material safety sheet)

Hepsera MSDS

Hepsera Synthesis Reference

No information avaliable

Hepsera Molecular Weight

501.471 g/mol

Hepsera Melting Point

No information avaliable

Hepsera H2O Solubility

19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.

Hepsera State


Hepsera LogP


Hepsera Dosage Forms

Tablet (10 mg)

Hepsera Indication

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Hepsera Pharmacology

Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

Hepsera Absorption

Approximate oral bioavailability is 59%.

Hepsera side effects and Toxicity

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

Hepsera Patient Information

Hepsera Organisms Affected

Hepatitis B virus