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PMEA Brand names, PMEA Analogs

PMEA Brand Names Mixture

  • No information avaliable

PMEA Chemical_Formula


PMEA RX_link

PMEA fda sheet


PMEA msds (material safety sheet)


PMEA Synthesis Reference

No information avaliable

PMEA Molecular Weight

501.471 g/mol

PMEA Melting Point

No information avaliable

PMEA H2O Solubility

19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.

PMEA State




PMEA Dosage Forms

Tablet (10 mg)

PMEA Indication

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

PMEA Pharmacology

Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.

PMEA Absorption

Approximate oral bioavailability is 59%.

PMEA side effects and Toxicity

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

PMEA Patient Information

PMEA Organisms Affected

Hepatitis B virus