PMEA
PMEA Brand names, PMEA Analogs
PMEA Brand Names Mixture
- No information avaliable
PMEA Chemical_Formula
C20H32N5O8P
PMEA RX_link
http://www.rxlist.com/cgi/generic3/hepsera.htm
PMEA fda sheet
PMEA msds (material safety sheet)
PMEA Synthesis Reference
No information avaliable
PMEA Molecular Weight
501.471 g/mol
PMEA Melting Point
No information avaliable
PMEA H2O Solubility
19 mg/mL at pH 2.0 and 0.4 mg/mL at pH 7.2.
PMEA State
Solid
PMEA LogP
3.649
PMEA Dosage Forms
Tablet (10 mg)
PMEA Indication
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
PMEA Pharmacology
Adefovir dipivoxil a diester prodrug of adefovir. Adefovir is an acyclic nucleotide analog with activity against human hepatitis B virus (HBV). The concentration of adefovir that inhibited 50% of viral DNA synthesis (IC50) in vitro ranged from 0.2 to 2.5 μM in HBV transfected human hepatoma cell lines. The combination of adefovir with lamivudine showed additive anti-HBV activity.
PMEA Absorption
Approximate oral bioavailability is 59%.
PMEA side effects and Toxicity
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3–10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
PMEA Patient Information
PMEA Organisms Affected
Hepatitis B virus
