Pindolol
Pindolol Brand names, Pindolol Analogs
Pindolol Brand Names Mixture
- Viskazide 10/25tab (Hydrochlorothiazide + Pindolol)
- Viskazide 10/50tab (Hydrochlorothiazide + Pindolol)
Pindolol Chemical_Formula
C14H20N2O2
Pindolol RX_link
http://www.rxlist.com/cgi/generic3/pindolol.htm
Pindolol fda sheet
Pindolol msds (material safety sheet)
Pindolol Synthesis Reference
No information avaliable
Pindolol Molecular Weight
248.321 g/mol
Pindolol Melting Point
167-171 oC
Pindolol H2O Solubility
7880 mg/L
Pindolol State
Solid
Pindolol LogP
2.525
Pindolol Dosage Forms
Tablet
Pindolol Indication
For the management of hypertension, edema, ventricular tachycardias, and atrial fibrillation.
Pindolol Pharmacology
Pindolol is a non-selective beta-adrenergic antagonist (beta-blocker) which possesses intrinsic sympathomimetic activity (ISA) in therapeutic dosage ranges but does not possess quinidine-like membrane stabilizing activity. Pindolol impairs AV node conduction and decreases sinus rate and may also increase plasma triglycerides and decrease HDL-cholesterol levels. Pindolol is nonpolar and hydrophobic, with low to moderate lipid solubility. Pindolol has little to no intrinsic sympathomimetic activity and, unlike some other beta-adrenergic blocking agents, pindolol has little direct myocardial depressant activity and does not have an anesthetic-like membrane-stabilizing action.
Pindolol Absorption
Rapidly and reproducibly absorbed (bioavailability greater than 95%).
Pindolol side effects and Toxicity
LD50=263 mg/kg (orally in rats). Signs of overdose include excessive bradycardia, cardiac failure, hypotension, and bronchospasm.
Pindolol Patient Information
Pindolol Organisms Affected
Humans and other mammals
