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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C10H15N
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RX_link
http://www.rxlist.com/cgi/generic/phenterm.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
149.233 g/mol
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Melting Point
205 oC
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H2O Solubility
18.6 g/L
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State
Solid
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LogP
2.194
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Dosage Forms
Capsule (30 mg)
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Indication
For the treatment and management of obesity.
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Pharmacology
Phentermine is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Phentermine hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
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Absorption
Phentermine is rapidly absorbed after oral ingestion.
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side effects and Toxicity
LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
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Patient Information
No information avaliable
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Organisms Affected
Humans and other mammals