Oestrone Sulphate
Oestrone Sulphate Brand names, Oestrone Sulphate Analogs
Oestrone Sulphate Brand Names Mixture
- Prempro (conjugated estrogens + medroxyprogesteron)
Oestrone Sulphate Chemical_Formula
C18H21NaO5S
Oestrone Sulphate RX_link
http://www.rxlist.com/cgi/generic/conest.htm
Oestrone Sulphate fda sheet
Oestrone Sulphate msds (material safety sheet)
Oestrone Sulphate Synthesis Reference
Bates, Cohen, U.S. Pat. 2,565,115 (1951)
Oestrone Sulphate Molecular Weight
372.412 g/mol
Oestrone Sulphate Melting Point
173 oC
Oestrone Sulphate H2O Solubility
0.0036 mg/ml
Oestrone Sulphate State
solid
Oestrone Sulphate LogP
No information avaliable
Oestrone Sulphate Dosage Forms
Tablet; Injection; Vaginal cream; Topical gel
Oestrone Sulphate Indication
For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Oestrone Sulphate Pharmacology
Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.
Oestrone Sulphate Absorption
Well absorbed
Oestrone Sulphate side effects and Toxicity
Nausea and vomiting
Oestrone Sulphate Patient Information
Oestrone Sulphate Organisms Affected
Humans and other mammals
