Estrone Sulfate Sodium
Estrone Sulfate Sodium Brand names, Estrone Sulfate Sodium Analogs
Estrone Sulfate Sodium Brand Names Mixture
- Prempro (conjugated estrogens + medroxyprogesteron)
Estrone Sulfate Sodium Chemical_Formula
C18H21NaO5S
Estrone Sulfate Sodium RX_link
http://www.rxlist.com/cgi/generic/conest.htm
Estrone Sulfate Sodium fda sheet
Estrone Sulfate Sodium msds (material safety sheet)
Estrone Sulfate Sodium Synthesis Reference
Bates, Cohen, U.S. Pat. 2,565,115 (1951)
Estrone Sulfate Sodium Molecular Weight
372.412 g/mol
Estrone Sulfate Sodium Melting Point
173 oC
Estrone Sulfate Sodium H2O Solubility
0.0036 mg/ml
Estrone Sulfate Sodium State
solid
Estrone Sulfate Sodium LogP
No information avaliable
Estrone Sulfate Sodium Dosage Forms
Tablet; Injection; Vaginal cream; Topical gel
Estrone Sulfate Sodium Indication
For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Estrone Sulfate Sodium Pharmacology
Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.
Estrone Sulfate Sodium Absorption
Well absorbed
Estrone Sulfate Sodium side effects and Toxicity
Nausea and vomiting
Estrone Sulfate Sodium Patient Information
Estrone Sulfate Sodium Organisms Affected
Humans and other mammals
