Sodium Estrone Sulfate
Sodium Estrone Sulfate Brand names, Sodium Estrone Sulfate Analogs
Sodium Estrone Sulfate Brand Names Mixture
- Prempro (conjugated estrogens + medroxyprogesteron)
Sodium Estrone Sulfate Chemical_Formula
C18H21NaO5S
Sodium Estrone Sulfate RX_link
http://www.rxlist.com/cgi/generic/conest.htm
Sodium Estrone Sulfate fda sheet
Sodium Estrone Sulfate msds (material safety sheet)
Sodium Estrone Sulfate Synthesis Reference
Bates, Cohen, U.S. Pat. 2,565,115 (1951)
Sodium Estrone Sulfate Molecular Weight
372.412 g/mol
Sodium Estrone Sulfate Melting Point
173 oC
Sodium Estrone Sulfate H2O Solubility
0.0036 mg/ml
Sodium Estrone Sulfate State
solid
Sodium Estrone Sulfate LogP
No information avaliable
Sodium Estrone Sulfate Dosage Forms
Tablet; Injection; Vaginal cream; Topical gel
Sodium Estrone Sulfate Indication
For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Sodium Estrone Sulfate Pharmacology
Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.
Sodium Estrone Sulfate Absorption
Well absorbed
Sodium Estrone Sulfate side effects and Toxicity
Nausea and vomiting
Sodium Estrone Sulfate Patient Information
Sodium Estrone Sulfate Organisms Affected
Humans and other mammals
