Estrone Sulphate
Estrone Sulphate Brand names, Estrone Sulphate Analogs
Estrone Sulphate Brand Names Mixture
- Prempro (conjugated estrogens + medroxyprogesteron)
Estrone Sulphate Chemical_Formula
C18H21NaO5S
Estrone Sulphate RX_link
http://www.rxlist.com/cgi/generic/conest.htm
Estrone Sulphate fda sheet
Estrone Sulphate msds (material safety sheet)
Estrone Sulphate Synthesis Reference
Bates, Cohen, U.S. Pat. 2,565,115 (1951)
Estrone Sulphate Molecular Weight
372.412 g/mol
Estrone Sulphate Melting Point
173 oC
Estrone Sulphate H2O Solubility
0.0036 mg/ml
Estrone Sulphate State
solid
Estrone Sulphate LogP
No information avaliable
Estrone Sulphate Dosage Forms
Tablet; Injection; Vaginal cream; Topical gel
Estrone Sulphate Indication
For the treatment of moderate to severe vasomotor symptoms associated with the menopause, atrophic vaginitis, osteoporosis, hypoestrogenism due to hypogonadism, castration, primary ovarian failure, breast cancer (for palliation only), and Advanced androgen-dependent carcinoma of the prostate (for palliation only)
Estrone Sulphate Pharmacology
Conjugated estrogens, a mixture of the water soluble salts of sulfate esters from estrone, equilin, 17 α-dihydroequilin, and other related steroids, may be derived from pregnant equine urine or yam and soy plants. Estrogens are important in the development and maintenance of the female reproductive system and secondary sex characteristics. They promote growth and development of the vagina, uterus, and fallopian tubes, and enlargement of the breasts. Indirectly, they contribute to the shaping of the skeleton, maintenance of tone and elasticity of urogenital structures, changes in the epiphyses of the long bones that allow for the pubertal growth spurt and its termination, growth of axillary and pubic hair, and pigmentation of the nipples and genitals. Decline of estrogenic activity at the end of the menstrual cycle can bring on menstruation, although the cessation of progesterone secretion is the most important factor in the mature ovulatory cycle. However, in the preovulatory or nonovulatory cycle, estrogen is the primary determinant in the onset of menstruation. Estrogens also affect the release of pituitary gonadotropins. The pharmacologic effects of conjugated estrogens are similar to those of endogenous estrogens.
Estrone Sulphate Absorption
Well absorbed
Estrone Sulphate side effects and Toxicity
Nausea and vomiting
Estrone Sulphate Patient Information
Estrone Sulphate Organisms Affected
Humans and other mammals
