Night Rest
Brand names,
Night Rest
Analogs
Night Rest
Brand Names Mixture
Night Rest
Chemical_Formula
C13H16N2O2
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RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
Szmuszkovicz et al., J. Org. Chem. 25, 857 (1960)
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Molecular Weight
232.278 g/mol
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Melting Point
117 oC
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H2O Solubility
No information avaliable
Night Rest
State
Solid
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LogP
1.536
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Dosage Forms
Capsules; Liquid; Lozenge; Tablets
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Indication
For the treatment of insomnia and jet lag
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Pharmacology
Melatonin is a hormone normally produced in the pineal gland and released into the blood. The essential amino acid L-tryptophan is a precursor in the synthesis of melatonin. It helps regulate sleep-wake cycles or the circadian rhythm. Production of melatonin is stimulated by darkness and inhibited by light. High levels of melatonin induce sleep and so consumption of the drug can be used to combat insomnia and jet lag.
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Absorption
The absorption and bioavailability of melatonin varies widely.
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side effects and Toxicity
Oral, rat: LD50 = >3200 mg/kg
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Patient Information
Night Rest
Organisms Affected
Humans and other mammals