Kantrex
Brand names,
Kantrex
Analogs
Kantrex
Brand Names Mixture
Kantrex
Chemical_Formula
C18H36N4O11
Kantrex
RX_link
http://www.rxlist.com/cgi/generic3/kanamycin.htm
Kantrex
fda sheet
Kantrex
msds (material safety sheet)
Kantrex
Synthesis Reference
No information avaliable
Kantrex
Molecular Weight
484.499 g/mol
Kantrex
Melting Point
No information avaliable
Kantrex
H2O Solubility
No information avaliable
Kantrex
State
Solid
Kantrex
LogP
-7.936
Kantrex
Dosage Forms
No information avaliable
Kantrex
Indication
For treatment of infections where one or more of the following are the known or suspected pathogens: E. coli, Proteus species (both indole-positive and indole-negative), E. aerogenes, K. pneumoniae, S. marcescens, and Acinetobacter species.
Kantrex
Pharmacology
Kanamycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses.
Kantrex
Absorption
No information avaliable
Kantrex
side effects and Toxicity
LD 50 - ORAL, MOUSE = 17500 MG/KG, LD 50 - ORAL, RAT = >4 GM/KG, LD 50 - ORAL, RABBIT = >3 GM/KG
Kantrex
Patient Information
No information avaliable
Kantrex
Organisms Affected
Enteric bacteria and other eubacteria