Natamycin

Natamycin Brand names, Natamycin Analogs

Natamycin Brand Names Mixture

No information avaliable

Natamycin Chemical_Formula

C₃₃H₄₇NO₁₃

Natamycin RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Natamycin fda sheet

Natamycin msds (material safety sheet)

Natamycin Synthesis Reference

No information avaliable

Natamycin Molecular Weight

665.725 g/mol

Natamycin Melting Point

290 ^oC

Natamycin H₂O Solubility

4100 mg/L

Natamycin State

Solid

Natamycin LogP

0.495

Natamycin Dosage Forms

Ophthalmic suspension (5%)

Natamycin Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Natamycin Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Natamycin Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Natamycin side effects and Toxicity