Nafcilin-1

Nafcilin-1 Brand names, Nafcilin-1 Analogs

Nafcilin-1 Brand Names Mixture

No information avaliable

Nafcilin-1 Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcilin-1 RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcilin-1 fda sheet

Nafcilin-1 msds (material safety sheet)

Nafcilin-1 Synthesis Reference

No information avaliable

Nafcilin-1 Molecular Weight

665.725 g/mol

Nafcilin-1 Melting Point

290 ^oC

Nafcilin-1 H₂O Solubility

4100 mg/L

Nafcilin-1 State

Solid

Nafcilin-1 LogP

0.495

Nafcilin-1 Dosage Forms

Ophthalmic suspension (5%)

Nafcilin-1 Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcilin-1 Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcilin-1 Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcilin-1 side effects and Toxicity