Nafcillinum [INN-Latin]

Nafcillinum [INN-Latin] Brand names, Nafcillinum [INN-Latin] Analogs

Nafcillinum [INN-Latin] Brand Names Mixture

No information avaliable

Nafcillinum [INN-Latin] Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcillinum [INN-Latin] RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcillinum [INN-Latin] fda sheet

Nafcillinum [INN-Latin] msds (material safety sheet)

Nafcillinum [INN-Latin] Synthesis Reference

No information avaliable

Nafcillinum [INN-Latin] Molecular Weight

665.725 g/mol

Nafcillinum [INN-Latin] Melting Point

290 ^oC

Nafcillinum [INN-Latin] H₂O Solubility

4100 mg/L

Nafcillinum [INN-Latin] State

Solid

Nafcillinum [INN-Latin] LogP

0.495

Nafcillinum [INN-Latin] Dosage Forms

Ophthalmic suspension (5%)

Nafcillinum [INN-Latin] Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcillinum [INN-Latin] Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcillinum [INN-Latin] Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcillinum [INN-Latin] side effects and Toxicity