Naphcillin

Naphcillin Brand names, Naphcillin Analogs

Naphcillin Brand Names Mixture

No information avaliable

Naphcillin Chemical_Formula

C₃₃H₄₇NO₁₃

Naphcillin RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Naphcillin fda sheet

Naphcillin msds (material safety sheet)

Naphcillin Synthesis Reference

No information avaliable

Naphcillin Molecular Weight

665.725 g/mol

Naphcillin Melting Point

290 ^oC

Naphcillin H₂O Solubility

4100 mg/L

Naphcillin State

Solid

Naphcillin LogP

0.495

Naphcillin Dosage Forms

Ophthalmic suspension (5%)

Naphcillin Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Naphcillin Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Naphcillin Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Naphcillin side effects and Toxicity