Nafcillin & VRC3375

Nafcillin & VRC3375 Brand names, Nafcillin & VRC3375 Analogs

Nafcillin & VRC3375 Brand Names Mixture

No information avaliable

Nafcillin & VRC3375 Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcillin & VRC3375 RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcillin & VRC3375 fda sheet

Nafcillin & VRC3375 msds (material safety sheet)

Nafcillin & VRC3375 Synthesis Reference

No information avaliable

Nafcillin & VRC3375 Molecular Weight

665.725 g/mol

Nafcillin & VRC3375 Melting Point

290 ^oC

Nafcillin & VRC3375 H₂O Solubility

4100 mg/L

Nafcillin & VRC3375 State

Solid

Nafcillin & VRC3375 LogP

0.495

Nafcillin & VRC3375 Dosage Forms

Ophthalmic suspension (5%)

Nafcillin & VRC3375 Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcillin & VRC3375 Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcillin & VRC3375 Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcillin & VRC3375 side effects and Toxicity