Nafcilline [INN-French]

Nafcilline [INN-French] Brand names, Nafcilline [INN-French] Analogs

Nafcilline [INN-French] Brand Names Mixture

No information avaliable

Nafcilline [INN-French] Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcilline [INN-French] RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcilline [INN-French] fda sheet

Nafcilline [INN-French] msds (material safety sheet)

Nafcilline [INN-French] Synthesis Reference

No information avaliable

Nafcilline [INN-French] Molecular Weight

665.725 g/mol

Nafcilline [INN-French] Melting Point

290 ^oC

Nafcilline [INN-French] H₂O Solubility

4100 mg/L

Nafcilline [INN-French] State

Solid

Nafcilline [INN-French] LogP

0.495

Nafcilline [INN-French] Dosage Forms

Ophthalmic suspension (5%)

Nafcilline [INN-French] Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcilline [INN-French] Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcilline [INN-French] Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcilline [INN-French] side effects and Toxicity