Nafcillin

Nafcillin Brand names, Nafcillin Analogs

Nafcillin Brand Names Mixture

No information avaliable

Nafcillin Chemical_Formula

C₃₃H₄₇NO₁₃

Nafcillin RX_link

http://www.rxlist.com/cgi/generic2/natamycin.htm

Nafcillin fda sheet

Nafcillin msds (material safety sheet)

Nafcillin Synthesis Reference

No information avaliable

Nafcillin Molecular Weight

665.725 g/mol

Nafcillin Melting Point

290 ^oC

Nafcillin H₂O Solubility

4100 mg/L

Nafcillin State

Solid

Nafcillin LogP

0.495

Nafcillin Dosage Forms

Ophthalmic suspension (5%)

Nafcillin Indication

For the treatment of fungal blepharitis, conjunctivitis, and keratitis caused by susceptible organisms including Fusarium solani keratitis.

Nafcillin Pharmacology

Natamycin is an antifungal drug for topical ophthalmic administration. It is a tetraene polyene antibiotic derived from Streptomyces natalensis. It possesses in vitro activity against a variety of yeast and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the activity against fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not effective in vitro against gram-positive or gram-negative bacteria. Topical administration appears to produce effective concentrations of natamycin within the corneal stroma but not in intraocular fluid.

Nafcillin Absorption

Systemic absorption should not be expected following topical administration, and as with other polyene antibiotics, absorption from the gastrointestinal tract is very poor.

Nafcillin side effects and Toxicity