Myelosanum, Busulphan
Myelosanum, Busulphan Brand names, Myelosanum, Busulphan Analogs
- Busulfex
- Busulphan
- Busulphane
- Butanedioldimethanesulfonate
- Buzulfan
- Citosulfan
- Leucosulfan
- Mablin
- Mielevcin
- Mielosan
- Mielucin
- Milecitan
- Mileran
- Misulban
- Mitosan
- Mitostan
- Myeleukon
- Myeloleukon
- Myelosan
- Myelosanum, Busulphan
- Mylecytan
- Myleran
- Myleran Tablets
- Nsc-750sulphabutin
- Sulfabutin
- Sulphabutin
- Tetramethylene Dimethane Sulfonate
- Tetramethylenester Kyseliny Methansulfonove
Myelosanum, Busulphan Brand Names Mixture
- None
Myelosanum, Busulphan Chemical_Formula
C6H14O6S2
Myelosanum, Busulphan RX_link
http://www.rxlist.com/cgi/generic2/busulfan.htm
Myelosanum, Busulphan fda sheet
Myelosanum, Busulphan msds (material safety sheet)
Myelosanum, Busulphan Synthesis Reference
U.S. pat. 2,917,432(1959)
Myelosanum, Busulphan Molecular Weight
246.304 g/mol
Myelosanum, Busulphan Melting Point
287 oC
Myelosanum, Busulphan H2O Solubility
6.9E+004 mg/L
Myelosanum, Busulphan State
Solid
Myelosanum, Busulphan LogP
-0.52
Myelosanum, Busulphan Dosage Forms
Solution; Tablet
Myelosanum, Busulphan Indication
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Myelosanum, Busulphan Pharmacology
Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Myelosanum, Busulphan Absorption
Completely absorbed from the gastrointestinal tract.
Myelosanum, Busulphan side effects and Toxicity
Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.
Myelosanum, Busulphan Patient Information
Myelosanum, Busulphan Organisms Affected
Humans and other mammals
