Nsc-750sulphabutin en es it fr

Nsc-750sulphabutin Brand names, Nsc-750sulphabutin Analogs

Nsc-750sulphabutin Brand Names Mixture

  • None

Nsc-750sulphabutin Chemical_Formula


Nsc-750sulphabutin RX_link


Nsc-750sulphabutin fda sheet

Nsc-750sulphabutin FDA

Nsc-750sulphabutin msds (material safety sheet)

Nsc-750sulphabutin MSDS

Nsc-750sulphabutin Synthesis Reference

U.S. pat. 2,917,432(1959)

Nsc-750sulphabutin Molecular Weight

246.304 g/mol

Nsc-750sulphabutin Melting Point

287 oC

Nsc-750sulphabutin H2O Solubility

6.9E+004 mg/L

Nsc-750sulphabutin State


Nsc-750sulphabutin LogP


Nsc-750sulphabutin Dosage Forms

Solution; Tablet

Nsc-750sulphabutin Indication

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.

Nsc-750sulphabutin Pharmacology

Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Nsc-750sulphabutin Absorption

Completely absorbed from the gastrointestinal tract.

Nsc-750sulphabutin side effects and Toxicity

Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.

Nsc-750sulphabutin Patient Information

Nsc-750sulphabutin Organisms Affected

Humans and other mammals