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Mitostan Brand names, Mitostan Analogs

Mitostan Brand Names Mixture

  • None

Mitostan Chemical_Formula


Mitostan RX_link

Mitostan fda sheet

Mitostan FDA

Mitostan msds (material safety sheet)

Mitostan MSDS

Mitostan Synthesis Reference

U.S. pat. 2,917,432(1959)

Mitostan Molecular Weight

246.304 g/mol

Mitostan Melting Point

287 oC

Mitostan H2O Solubility

6.9E+004 mg/L

Mitostan State


Mitostan LogP


Mitostan Dosage Forms

Solution; Tablet

Mitostan Indication

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.

Mitostan Pharmacology

Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Mitostan Absorption

Completely absorbed from the gastrointestinal tract.

Mitostan side effects and Toxicity

Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.

Mitostan Patient Information

Mitostan Organisms Affected

Humans and other mammals