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Mielevcin Brand names, Mielevcin Analogs

Mielevcin Brand Names Mixture

  • None

Mielevcin Chemical_Formula


Mielevcin RX_link


Mielevcin fda sheet

Mielevcin FDA

Mielevcin msds (material safety sheet)

Mielevcin MSDS

Mielevcin Synthesis Reference

U.S. pat. 2,917,432(1959)

Mielevcin Molecular Weight

246.304 g/mol

Mielevcin Melting Point

287 oC

Mielevcin H2O Solubility

6.9E+004 mg/L

Mielevcin State


Mielevcin LogP


Mielevcin Dosage Forms

Solution; Tablet

Mielevcin Indication

For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.

Mielevcin Pharmacology

Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.

Mielevcin Absorption

Completely absorbed from the gastrointestinal tract.

Mielevcin side effects and Toxicity

Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.

Mielevcin Patient Information

Mielevcin Organisms Affected

Humans and other mammals