Misulban
Misulban Brand names, Misulban Analogs
- Busulfex
- Busulphan
- Busulphane
- Butanedioldimethanesulfonate
- Buzulfan
- Citosulfan
- Leucosulfan
- Mablin
- Mielevcin
- Mielosan
- Mielucin
- Milecitan
- Mileran
- Misulban
- Mitosan
- Mitostan
- Myeleukon
- Myeloleukon
- Myelosan
- Myelosanum, Busulphan
- Mylecytan
- Myleran
- Myleran Tablets
- Nsc-750sulphabutin
- Sulfabutin
- Sulphabutin
- Tetramethylene Dimethane Sulfonate
- Tetramethylenester Kyseliny Methansulfonove
Misulban Brand Names Mixture
- None
Misulban Chemical_Formula
C6H14O6S2
Misulban RX_link
http://www.rxlist.com/cgi/generic2/busulfan.htm
Misulban fda sheet
Misulban msds (material safety sheet)
Misulban Synthesis Reference
U.S. pat. 2,917,432(1959)
Misulban Molecular Weight
246.304 g/mol
Misulban Melting Point
287 oC
Misulban H2O Solubility
6.9E+004 mg/L
Misulban State
Solid
Misulban LogP
-0.52
Misulban Dosage Forms
Solution; Tablet
Misulban Indication
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Misulban Pharmacology
Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Misulban Absorption
Completely absorbed from the gastrointestinal tract.
Misulban side effects and Toxicity
Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.
Misulban Patient Information
Misulban Organisms Affected
Humans and other mammals
