Tetramethylenester Kyseliny Methansulfonove
Tetramethylenester Kyseliny Methansulfonove Brand names, Tetramethylenester Kyseliny Methansulfonove Analogs
- Busulfex
- Busulphan
- Busulphane
- Butanedioldimethanesulfonate
- Buzulfan
- Citosulfan
- Leucosulfan
- Mablin
- Mielevcin
- Mielosan
- Mielucin
- Milecitan
- Mileran
- Misulban
- Mitosan
- Mitostan
- Myeleukon
- Myeloleukon
- Myelosan
- Myelosanum, Busulphan
- Mylecytan
- Myleran
- Myleran Tablets
- Nsc-750sulphabutin
- Sulfabutin
- Sulphabutin
- Tetramethylene Dimethane Sulfonate
- Tetramethylenester Kyseliny Methansulfonove
Tetramethylenester Kyseliny Methansulfonove Brand Names Mixture
- None
Tetramethylenester Kyseliny Methansulfonove Chemical_Formula
C6H14O6S2
Tetramethylenester Kyseliny Methansulfonove RX_link
http://www.rxlist.com/cgi/generic2/busulfan.htm
Tetramethylenester Kyseliny Methansulfonove fda sheet
Tetramethylenester Kyseliny Methansulfonove msds (material safety sheet)
Tetramethylenester Kyseliny Methansulfonove Synthesis Reference
U.S. pat. 2,917,432(1959)
Tetramethylenester Kyseliny Methansulfonove Molecular Weight
246.304 g/mol
Tetramethylenester Kyseliny Methansulfonove Melting Point
287 oC
Tetramethylenester Kyseliny Methansulfonove H2O Solubility
6.9E+004 mg/L
Tetramethylenester Kyseliny Methansulfonove State
Solid
Tetramethylenester Kyseliny Methansulfonove LogP
-0.52
Tetramethylenester Kyseliny Methansulfonove Dosage Forms
Solution; Tablet
Tetramethylenester Kyseliny Methansulfonove Indication
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Tetramethylenester Kyseliny Methansulfonove Pharmacology
Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Tetramethylenester Kyseliny Methansulfonove Absorption
Completely absorbed from the gastrointestinal tract.
Tetramethylenester Kyseliny Methansulfonove side effects and Toxicity
Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.
Tetramethylenester Kyseliny Methansulfonove Patient Information
Tetramethylenester Kyseliny Methansulfonove Organisms Affected
Humans and other mammals
