Mielucin
Mielucin Brand names, Mielucin Analogs
- Busulfex
- Busulphan
- Busulphane
- Butanedioldimethanesulfonate
- Buzulfan
- Citosulfan
- Leucosulfan
- Mablin
- Mielevcin
- Mielosan
- Mielucin
- Milecitan
- Mileran
- Misulban
- Mitosan
- Mitostan
- Myeleukon
- Myeloleukon
- Myelosan
- Myelosanum, Busulphan
- Mylecytan
- Myleran
- Myleran Tablets
- Nsc-750sulphabutin
- Sulfabutin
- Sulphabutin
- Tetramethylene Dimethane Sulfonate
- Tetramethylenester Kyseliny Methansulfonove
Mielucin Brand Names Mixture
- None
Mielucin Chemical_Formula
C6H14O6S2
Mielucin RX_link
http://www.rxlist.com/cgi/generic2/busulfan.htm
Mielucin fda sheet
Mielucin msds (material safety sheet)
Mielucin Synthesis Reference
U.S. pat. 2,917,432(1959)
Mielucin Molecular Weight
246.304 g/mol
Mielucin Melting Point
287 oC
Mielucin H2O Solubility
6.9E+004 mg/L
Mielucin State
Solid
Mielucin LogP
-0.52
Mielucin Dosage Forms
Solution; Tablet
Mielucin Indication
For use in combination with cyclophosphamide as a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation for chronic myelogenous leukemia.
Mielucin Pharmacology
Busulfan is an antineoplastic in the class of alkylating agents and is used to treat various forms of cancer. Alkylating agents are so named because of their ability to add alkyl groups to many electronegative groups under conditions present in cells. They stop tumor growth by cross-linking guanine bases in DNA double-helix strands - directly attacking DNA. This makes the strands unable to uncoil and separate. As this is necessary in DNA replication, the cells can no longer divide. In addition, these drugs add methyl or other alkyl groups onto molecules where they do not belong which in turn inhibits their correct utilization by base pairing and causes a miscoding of DNA. Alkylating agents are cell cycle-nonspecific. Alkylating agents work by three different mechanisms all of which achieve the same end result - disruption of DNA function and cell death.
Mielucin Absorption
Completely absorbed from the gastrointestinal tract.
Mielucin side effects and Toxicity
Signs of overdose include allergic reaction, unusual bleeding or bruising, sudden weakness or unusual fatigue, persistent cough, congestion, or shortness of breath; flank, stomach or joint pain; pronounced nausea, vomiting, diarrhea, dizziness, confusion, or darkening of the skin, chills, fever, collapse, and loss of consciousness.
Mielucin Patient Information
Mielucin Organisms Affected
Humans and other mammals
