Metformin
Metformin Brand names, Metformin Analogs
Metformin Brand Names Mixture
- No information avaliable
Metformin Chemical_Formula
C4H11N5
Metformin RX_link
http://www.rxlist.com/cgi/generic4/glumetza.htm
Metformin fda sheet
Metformin msds (material safety sheet)
Metformin Synthesis Reference
No information avaliable
Metformin Molecular Weight
129.164 g/mol
Metformin Melting Point
223-226 oC
Metformin H2O Solubility
Freely soluble as HCl salt
Metformin State
Solid
Metformin LogP
-0.267
Metformin Dosage Forms
Extended release tablet (500 mg or 1000 mg)
Metformin Indication
For use as an adjunct to diet and exercise to improve glycemic control in adult patients (18 years and older) with type 2 diabetes.
Metformin Pharmacology
Metformin is an antihyperglycemic agent, which improves glucose tolerance in patients with type 2 diabetes, lowering both basal and postprandial plasma glucose. Metformin is not chemically or pharmacologically related to any other classes of oral antihyperglycemic agents. Unlike sulfonylureas, metformin does not produce hypoglycemia in either patients with type 2 diabetes or normal subjects and does not cause hyperinsulinemia. With metformin therapy, insulin secretion remains unchanged while fasting insulin levels and daylong plasma insulin response may actually decrease.
Metformin Absorption
Absorbed over 6 hours, bioavailability is 50 to 60% under fasting conditions. Food delays absorption.
Metformin side effects and Toxicity
Acute oral toxicity (LD50): 350 mg/kg [Rabbit]. It would be expected that adverse reactions of a more intense character including epigastric discomfort, nausea, and vomiting followed by diarrhea, drowsiness, weakness, dizziness, malaise and headache might be seen.
Metformin Patient Information
Metformin Organisms Affected
Humans and other mammals
