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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C21H23ClFNO2
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RX_link
http://www.rxlist.com/cgi/generic/haloper.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
P. A. J. Janssen, Belg. pat. 577,977 (1959), C.A. 54, 4630c (1960); idem, Brit. pat. 895,309 corresp to U.S. pat. 3,438,991 (1962, 1969 to Janssen).
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Molecular Weight
375.864 g/mol
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Melting Point
151.5 oC
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H2O Solubility
14 mg/L
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State
Solid
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LogP
4.362
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Dosage Forms
Injection; Oral solution; Tablet
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Indication
For the treatment of schizophrenic patients who require prolonged parenteral antipsychotic therapy also used in Tourette's syndrome and Severe hyperactivity.
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Pharmacology
Haloperidol is a psychotropic agent indicated for the treatment of schizophrenia. It also exerts sedative and antiemetic activity. Haloperidol has actions at all levels of the central nervous system-primarily at subcortical levels-as well as on multiple organ systems. Haloperidol has strong antiadrenergic and weaker peripheral anticholinergic activity; ganglionic blocking action is relatively slight. It also possesses slight antihistaminic and antiserotonin activity.
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Absorption
Oral-60%
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side effects and Toxicity
LD50=165 mg/kg (rats, oral)
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Patient Information
PRD00538_PI.txt
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Organisms Affected
Humans and other mammals